Author(s):
Shila Barman, Arindam Sarkar, Adarsha Bachhar, Sanchita Mandal
Email(s):
smandal.pharmacy@jadavpuruniversity.in , Sanchitaju2@gmail.com
DOI:
10.52711/2231-5659.2026.00033 
Address:
Shila Barman, Arindam Sarkar, Adarsha Bachhar, Sanchita Mandal*
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India, 700032.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2026
ABSTRACT:
The recent innovations of drug delivery technologies focus on issues like rapid gastric emptying and small gastric capacity. Of these developments, gastroretentive systems, particularly raft-forming systems, have a high potential since they produce a floating, gel-like raft in the stomach extending residence time and modulating drug release. This paper compared the effects of Sodium Alginate (SA), Guar Gum (GG), and other grades of Hydroxypropyl Methylcellulose (HPMC) on the formation of raft when metronidazole was used as a model drug. SA and calcium carbonate were used as the source of divalent cation along with four HPMC grades, namely, K100M, K40M, K15M, and K4M. Formulations were evaluated based on physical appearance, pH, in-vitro gelling capacity, buoyancy, shear- stress viscosity, raft density, floating duration, raft volume and raft thickness, resilience, swelling index and FTIR. Everything was similar in preparation, but the colour of the product of HPMC K100M was more intense. The pH was between 2 and 3, with the highest value of 3 which was obtained using HPMC K100M. It also exhibited the shortest gel time of 5s. All formulations remained in suspension during a period of more than 24h and raft toughness throughout 4h. On the whole, the SA/HPMC K100M mixture showed the best performance, which is why this polymer should be used in further gastroretentive formulations studies.
Cite this article:
Shila Barman, Arindam Sarkar, Adarsha Bachhar, Sanchita Mandal. Effects of Different Polymers Inter Polymer Network on Alginate Floating Raft Design. Asian Journal of Research in Pharmaceutical Sciences. 2026; 16(3):217-4. doi: 10.52711/2231-5659.2026.00033
Cite(Electronic):
Shila Barman, Arindam Sarkar, Adarsha Bachhar, Sanchita Mandal. Effects of Different Polymers Inter Polymer Network on Alginate Floating Raft Design. Asian Journal of Research in Pharmaceutical Sciences. 2026; 16(3):217-4. doi: 10.52711/2231-5659.2026.00033 Available on: https://www.ajpsonline.com/AbstractView.aspx?PID=2026-16-3-2
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