Author(s):
Shalini Shinde, Khushi Mhetras, Tejashri Atigre, Shreya Sawant, Akash Thombre, Aniket Thanekar, Dhanraj Jadge
Email(s):
ms.shalinishinde177@gmail.com
DOI:
10.52711/2231-5659.2026.00002 
Address:
Shalini Shinde1*, Khushi Mhetras1, Tejashri Atigre1, Shreya Sawant1, Akash Thombre2, Aniket Thanekar1, Dhanraj Jadge1
1Department of Pharmaceutical Chemistry, Womens College of Pharmacy, Peth-Vadgaon 416112, India.
2Department of Pharmaceutical Chemistry, Ashokrao Mane Institute of Pharmacy, Ambap 416112, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 1,
Year - 2026
ABSTRACT:
Joints are the most common targets of the immune system's erroneous assault in rheumatoid arthritis (RA), an autoimmune disease. The joints, particularly ones in the hands, wrists, and knees, tend to become inflamed. Untreated RA can cause abnormalities and damage to joints over time. NF-?B and PI3Ks enzymes play an important role in intracellular signaling channels. This study finds the potential of NF-?B and PI3Ks inhibitors. The phytochemicals of plants Callicarpa macrophylla and Hiptage benghalensis were subjected to molecular docking against NF-?B and PI3Ks, and the phytochemicals showed good binding affinity. According to the results, alpha-Amyrin has a higher binding affinity. Also, the ADMET and Drug-Likeness properties study suggests that these chemicals have the potential to provide anti-inflammatory effects.
Cite this article:
Shalini Shinde, Khushi Mhetras, Tejashri Atigre, Shreya Sawant, Akash Thombre, Aniket Thanekar, Dhanraj Jadge. In Silico Analysis and Molecular Docking Studies of Phytochemicals of Calicarpa Macrophylla and Hiptage Benghalensis against Nf-Kb and Pi3k for Rheumatoid Arthritis. Asian Journal of Research in Pharmaceutical Sciences. 2026; 16(1):9-4. doi: 10.52711/2231-5659.2026.00002
Cite(Electronic):
Shalini Shinde, Khushi Mhetras, Tejashri Atigre, Shreya Sawant, Akash Thombre, Aniket Thanekar, Dhanraj Jadge. In Silico Analysis and Molecular Docking Studies of Phytochemicals of Calicarpa Macrophylla and Hiptage Benghalensis against Nf-Kb and Pi3k for Rheumatoid Arthritis. Asian Journal of Research in Pharmaceutical Sciences. 2026; 16(1):9-4. doi: 10.52711/2231-5659.2026.00002 Available on: https://www.ajpsonline.com/AbstractView.aspx?PID=2026-16-1-2
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